Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma

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Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma.

BACKGROUND A phase II trial was performed to evaluate the efficacy of a dose-dense, 7 days on/7 days off schedule of temozolomide for patients with recurrent high-grade gliomas (HGG). METHODS Sixty patients with recurrent HGG received temozolomide at 150 mg/m(2)/day on days 1-7 and days 15-21 during each 4-week cycle. The primary endpoint was 6-month progression-free survival (PFS-6), with a ...

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ژورنال

عنوان ژورنال: Neuro-Oncology

سال: 2014

ISSN: 1522-8517,1523-5866

DOI: 10.1093/neuonc/nou044